Programa de Pós-Graduação em Bioquímica – Graduate Program in Biochemistry

Laboratory of Biochemistry and Cell Signaling

Prof. Kviecinski holds an undergraduate degree in Pharmacy – Clinical Analysis from the Universidade Comunitária da Região de Chapecó, a master’s degree in Pharmacy and a doctoral degree in Biochemistry from the Universidade Federal de Santa Catarina (Florianopolis, Brazil). He performed doctoral research at the Louvain Drug Research Institute (Université Catholique de Louvain, Belgium) and postdoctoral research at the Life Sciences Department of GlaxoSmithKline’s Medicines Research Center (United Kingdom).

“His line of research is focused on translational studies that assess biochemical and immune responses to new drugs and biological compounds for cancer and immune-mediated diseases”

Ongoing projects:

a) Study of the effects and molecular mechanisms underlying exposure to toxicants in rat cells and tissues, as well as immortalized cells in culture.
b) Involvement of inflammatory processes and the redox system in neurotoxicity induced by maternal exposure to glyphosate.
c) Antitumor activity and mechanism of action of naphthalene imidazo[1,2 a] selenylated pyridine*
* Currently recruiting Master students (Biochemistry) and Scientific Initiation students.

Main publications: 

– Retinoic acid synergizes ATO-mediated cytotoxicity by precluding Nrf2 activity in AML cells (doi: 10.1038/bjc.2014.380).

– Dietary supplementation with procyanidin-rich Pinus pinaster extract is associated with attenuated Ehrlich tumor development in mice (doi: 10.1016/j.nutres.2018.11.005).

– Study of the potential adverse effects caused by the dermal application of Dillenia indica L. fruit extract standardized to betulinic acid in rodents (doi: 10.1371/journal.pone.0217718).

– DNA damage and inhibition of Akt pathway in MCF-7 cells and Ehrlich tumor in mice treated with 1,4-naphthoquinones in combination with ascorbate (doi: 10.1155/2015/495305).

– Healing effect of Dillenia indica fruit extracts standardized to betulinic acid on ultraviolet radiation-induced psoriasis-like wounds in rats (doi: 10.1080/13880209.2016.1266672).