Programa de Pós-Graduação em Bioquímica – Graduate Program in Biochemistry

Cellular Defenses Laboratory (LABDEF)

Prof. Dafré holds an undergraduate degree in Biological Sciences from the Universidade Federal de Santa Catarina and a master’s degree and a doctoral degree in Physiology from the Universidade Federal do Rio Grande do Sul. He carried out postdoctoral research at the Johann Wolfgang Goethe Universitaet, Germany, at Otago University, New Zealand, and at Salk Institute, United States.

“His research is focused on the study of antioxidant defenses and modulation of the cellular redox state in stressful situations”

Main Publications:

Upregulating Nrf2-dependent antioxidant defenses in Pacific oysters Crassostrea gigas: Investigating the Nrf2/Keap1 pathway in bivalves. Comp Biochem Physiol C Toxicol Pharmacol. 2017; 195:16-26. 

Methylglyoxal-induced AMPK activation leads to autophagic degradation of thioredoxin 1 and glyoxalase 2 in HT22 nerve cells. Free Radic Biol Med. 2017; 108:270-279.

Inhibition of reductase systems by 2-AAPA modulates peroxiredoxin oxidation and mitochondrial function in A172 glioblastoma cells. Toxicol In Vitro. 2017; 42:273-280.

Repeated Methylglyoxal Treatment Depletes Dopamine in the Prefrontal Cortex, and Causes Memory Impairment and Depressive-Like Behavior in Mice. Neurochem Res. 2020; 45(2):354-370.