Programa de Pós-Graduação em Bioquímica – Graduate Program in Biochemistry

LabCancer – Cancer Biochemistry and Pharmacology Laboratory

Prof. Zanotto Filho holds an undergraduate degree in Pharmacy and a doctoral degree in Biochemistry from the Universidade Federal do Rio Grande do Sul (UFRGS). He has carried out postdoctoral research at the University of Texas Health Science Center (UTHealth), United States.

“His research is focused on understanding how oncogenes and tumor suppressors loss- and gain-of-functions may modulate mechanisms not limited to their classical role in cell cycle control and DNA damage response, but also those associated with the tumor microenvironment, intratumoral inflammation, and metastatic spreading”

Main Publications: 

COX-2 promotes mammary adipose tissue inflammation, local estrogen biosynthesis, and carcinogenesis in high-sugar/fat diet treated mice. Cancer Lett. 2021; 502:44-57. 

Efficient identification of novel anti-glioma lead compounds by machine learning models. European Journal of Medicinal Chemistry. 2020; 189: 111981-111995.

Classification algorithms applied to blood-based transcriptome meta-analysis to predict idiopathic Parkinson’s disease. Computers in Biology and Medicine, 2020. 124:103925-103935.

Sorafenib improves alkylating therapy by blocking induced inflammation, invasion and angiogenesis in breast cancer cells. Cancer Letter. 2018; 425-101-115.