Fátima Regina Mena Barreto Silva

Hormones & Signal Transduction Laboratory /
Electrophysiology & Patch Clamp Laboratory (NUBIOCEL)

Prof. Silva holds an undergraduate degree in Chemistry from the Universidade Católica de Pelotas and a doctoral degree in Biological Sciences: Biochemistry from the Universidade Federal do Rio Grande do Sul (UFRGS). She carried out postdoctoral research at the Université de CAEN, Normandy, France. She held a scholarship in Tokyo, Japan (JICA), and she was a “Visiting Scientist” at the University of California, Riverside, UCR USA (in 2000 and 2002). She currently holds the position of Enseignant-Chercheur Etranger at the Université de CAEN (2018 – current) and is a full Professor at the Universidade Federal de Santa Catarina (UFSC).

She has been engaged in International Cooperations involving graduate projects and students in: UCR/USA, UNICAEN and Sorbonne Universités/France, De Monfort University/UK, National University of Colombia/Colombia, and University of Guelph/Canada.

“Her research is focused on cell signaling of hormones, natural, synthetic and xenobiotic compounds in pathophysiological processes of male reproductive function and diabetes”

Courses in the PPGBQA:
a) Updates on molecular biology techniques
b) Steroids I and II

Ongoing projects:
a) Study of the effect and mechanism of action of natural products, hormones, vitamins, analogs, and metabolites in biological systems in vivo and in vitro.
b) Study the effect and mechanism of action of novel compounds derived from chalcones of interest for antidiabetic therapy.
c) Endocrine impact of natural, synthetic, endogenous, and xenobiotic compounds on diabetes and infertility.

Main publications: 

Pyriproxyfen induces intracellular calcium overload and alters antioxidant defenses in Danio rerio testis that may influence ongoing spermatogenesis. Environmental Pollution, v. 270, p. 116055, 2021.

Dibutyl phthalate rapidly alters calcium homeostasis in the gills of Danio rerio. Chemosphere, v. 258, p. 127408-127419, 2020.

Insulin stimulus-secretion coupling is triggered by a novel thiazolidinedione/sulfonylurea hybrid in rat pancreatic islets. Journal of Cellular Physiology v. 234, p. 509-520, 2018.

Sulfonyl(thio)urea derivative induction of insulin secretion is mediated by potassium, calcium, and sodium channel signal transduction. Journal of Cellular Physiology v. 234, p. 10138-10147, 2018.