Programa de Pós-Graduação em Bioquímica – Graduate Program in Biochemistry

Experimental Neuropathology Laboratory (LEN)

Prof. Farina holds an undergraduate degree in Pharmacy (Clinical and Toxicological Analysis), a master’s degree in Biological Sciences (Toxicological Biochemistry) at the Universidade Federal de Santa Maria, and a doctoral degree in Biological Sciences (Biochemistry) at the Universidade Federal do Rio Grande do Sul. He carried out postdoctoral research in Neurotoxicology at the Instituto de Investigaciones Biomédicas in Barcelona, Spain. 

“His line of research is focused on the study of mechanisms related to neuropathological processes, with a focus on redox biology, neurotoxicology and neuroprotection”.

Main Publications: 

New Probucol Analogues Inhibit Ferroptosis, Improve Mitochondrial Parameters, and Induce Glutathione Peroxidase in HT22 Cells. Molecular Neurobiology, 2020. 57: 3273-3290.

Probucol, a lipid-lowering drug, prevents cognitive and hippocampal synaptic impairments induced by amyloid β peptide in mice. Exp Neurol. 2012; 233(2):767-75. 

Methylmercury neurotoxicity is associated with inhibition of the antioxidant enzyme glutathione peroxidase. Free Radic Biol Med. 2009; 47(4):449-57. 

Prenatal methylmercury exposure hampers glutathione antioxidant system ontogenesis and causes long-lasting oxidative stress in the mouse brain. Toxicol Appl Pharmacol. 2008; 227(1):147-54.