Programa de Pós-Graduação em Bioquímica – Graduate Program in Biochemistry

Structure, metabolism and signaling of lipids in health and disease

The field of lipid signaling in health and disease is in rapid growth, and it is our intention to capture this momentum and excitement with a school and a mini-symposium focused on lipid metabolism, immunity and neurosciences.

Free as well as esterified fatty acids are key components of lipoproteins and cell membranes that can be affected by oxidative and nitrative stress conditions, characteristics of chronic inflammatory disorders. Nitric oxide-derived species react with unsaturated fatty acids yielding a variety of oxidized and nitrated products. In particular, nitroderivatives of long-chain unsaturated fatty acids containing a nitro-alkene group (NO2-FA) have been identified, detected, and quantified in plasma as well as in cell membranes and tissue. They modulate metabolic as well as inflammatory signaling pathways, that is, induction of phase II antioxidant enzymes such as hemoxygenase 1. In this course and lectures, we will discuss the key biological properties of NO2-FA in terms of modulation of the expression and activity of enzymes as well as their capacity to modulate lipid oxidation, nitric oxide production, and signaling.

Course: Structure, metabolism and signaling of lipids in health and disease

Graduate Program in Biochemistry, UFSC
Invited speaker: Prof. Dr. Andrés Trostchansky, University of Pittsburg
Host: Ariane Zamoner and Alexandra Latini
Location: Room SIPG209, 2nd floor, block C, new CCB building, UFSC
Date: March 4 – 10, 2020; 9-12 am and 2-5 pm

Mini-Symposium: Symposium CAPES/PrInt of the Graduate Programs in Biochemistry, Pharmacology and Medical Sciences

March 4 – 10, 2020
Host: Rui Daniel Prediger, Katia Lin, Roger Walz, Ariane Zamoner and Alexandra Latini
Location: Room FMC15, ground floor, block D, new CCB building, UFSC
Date: March 4, 2020; 2-4:30 pm

Lectures

Neuroinflammation in Amyotrophic Lateral Sclerosis and Parkinson Disease
Prof. Dr. Andrés Trostchansky, University of Pittsburg, USA
Biography

Context-Dependant Neuro-Immunology
Prof. Dr. Sebastien Talbot, University of Montreal, Canada
Biography